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1.

Enabling structure-based drug discovery utilizing predicted models.

Miller, Edward B; Hwang, Howook; Shelley, Mee; Placzek, Andrew; Rodrigues, João P G L M; Suto, Robert K; Wang, Lingle; Akinsanya, Karen; Abel, Robert.

Cell; 187(3): 521-525, 2024 Feb 01.

Artículo en Inglés | MEDLINE | ID: mdl-38306979

2.

Structure-based design of non-hypertrophic apelin receptor modulator.

Wang, Wei-Wei; Ji, Su-Yu; Zhang, Wenjia; Zhang, Junxia; Cai, Chenxi; Hu, Rubi; Zang, Shao-Kun; Miao, Luwei; Xu, Haomang; Chen, Li-Nan; Yang, Zongkuai; Guo, Jia; Qin, Jiao; Shen, Dan-Dan; Liang, Ping; Zhang, Yan; Zhang, Yan.

Cell; 187(6): 1460-1475.e20, 2024 Mar 14.

Artículo en Inglés | MEDLINE | ID: mdl-38428423

3.

A general chemical principle for creating closure-stabilizing integrin inhibitors.

Lin, Fu-Yang; Li, Jing; Xie, Yonghua; Zhu, Jianghai; Huong Nguyen, Thi Thu; Zhang, Yonghui; Zhu, Jieqing; Springer, Timothy A.

Cell; 185(19): 3533-3550.e27, 2022 09 15.

Artículo en Inglés | MEDLINE | ID: mdl-36113427

4.

From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease.

Brown, Alastair J H; Bradley, Sophie J; Marshall, Fiona H; Brown, Giles A; Bennett, Kirstie A; Brown, Jason; Cansfield, Julie E; Cross, David M; de Graaf, Chris; Hudson, Brian D; Dwomoh, Louis; Dias, João M; Errey, James C; Hurrell, Edward; Liptrot, Jan; Mattedi, Giulio; Molloy, Colin; Nathan, Pradeep J; Okrasa, Krzysztof; Osborne, Greg; Patel, Jayesh C; Pickworth, Mark; Robertson, Nathan; Shahabi, Shahram; Bundgaard, Christoffer; Phillips, Keith; Broad, Lisa M; Goonawardena, Anushka V; Morairty, Stephen R; Browning, Michael; Perini, Francesca; Dawson, Gerard R; Deakin, John F W; Smith, Robert T; Sexton, Patrick M; Warneck, Julie; Vinson, Mary; Tasker, Tim; Tehan, Benjamin G; Teobald, Barry; Christopoulos, Arthur; Langmead, Christopher J; Jazayeri, Ali; Cooke, Robert M; Rucktooa, Prakash; Congreve, Miles S; Weir, Malcolm; Tobin, Andrew B.

Cell; 184(24): 5886-5901.e22, 2021 11 24.

Artículo en Inglés | MEDLINE | ID: mdl-34822784

5.

Targeting Strategies for Tissue-Specific Drug Delivery.

Zhao, Zongmin; Ukidve, Anvay; Kim, Jayoung; Mitragotri, Samir.

Cell; 181(1): 151-167, 2020 04 02.

Artículo en Inglés | MEDLINE | ID: mdl-32243788

6.

Impact of GPCR Structures on Drug Discovery.

Congreve, Miles; de Graaf, Chris; Swain, Nigel A; Tate, Christopher G.

Cell; 181(1): 81-91, 2020 04 02.

Artículo en Inglés | MEDLINE | ID: mdl-32243800

7.

Structures and functions of coronavirus replication-transcription complexes and their relevance for SARS-CoV-2 drug design.

Malone, Brandon; Urakova, Nadya; Snijder, Eric J; Campbell, Elizabeth A.

Nat Rev Mol Cell Biol; 23(1): 21-39, 2022 01.

Artículo en Inglés | MEDLINE | ID: mdl-34824452

8.

Crystal Structure of the Human Cannabinoid Receptor CB2.

Li, Xiaoting; Hua, Tian; Vemuri, Kiran; Ho, Jo-Hao; Wu, Yiran; Wu, Lijie; Popov, Petr; Benchama, Othman; Zvonok, Nikolai; Locke, K'ara; Qu, Lu; Han, Gye Won; Iyer, Malliga R; Cinar, Resat; Coffey, Nathan J; Wang, Jingjing; Wu, Meng; Katritch, Vsevolod; Zhao, Suwen; Kunos, George; Bohn, Laura M; Makriyannis, Alexandros; Stevens, Raymond C; Liu, Zhi-Jie.

Cell; 176(3): 459-467.e13, 2019 01 24.

Artículo en Inglés | MEDLINE | ID: mdl-30639103

9.

Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target.

Zhang, Bing; Li, Jun; Yang, Xiaolin; Wu, Lijie; Zhang, Jia; Yang, Yang; Zhao, Yao; Zhang, Lu; Yang, Xiuna; Yang, Xiaobao; Cheng, Xi; Liu, Zhijie; Jiang, Biao; Jiang, Hualiang; Guddat, Luke W; Yang, Haitao; Rao, Zihe.

Cell; 176(3): 636-648.e13, 2019 01 24.

Artículo en Inglés | MEDLINE | ID: mdl-30682372

10.

Principles of Protein Stability and Their Application in Computational Design.

Goldenzweig, Adi; Fleishman, Sarel J.

Annu Rev Biochem; 87: 105-129, 2018 06 20.

Artículo en Inglés | MEDLINE | ID: mdl-29401000

11.

Directed Evolution of Protein Catalysts.

Zeymer, Cathleen; Hilvert, Donald.

Annu Rev Biochem; 87: 131-157, 2018 06 20.

Artículo en Inglés | MEDLINE | ID: mdl-29494241

12.

Understanding and Improving the Activity of Flavin-Dependent Halogenases via Random and Targeted Mutagenesis.

Andorfer, Mary C; Lewis, Jared C.

Annu Rev Biochem; 87: 159-185, 2018 06 20.

Artículo en Inglés | MEDLINE | ID: mdl-29589959

13.

Ribosome-Targeting Antibiotics: Modes of Action, Mechanisms of Resistance, and Implications for Drug Design.

Lin, Jinzhong; Zhou, Dejian; Steitz, Thomas A; Polikanov, Yury S; Gagnon, Matthieu G.

Annu Rev Biochem; 87: 451-478, 2018 06 20.

Artículo en Inglés | MEDLINE | ID: mdl-29570352

14.

Common Features of Enveloped Viruses and Implications for Immunogen Design for Next-Generation Vaccines.

Rey, Felix A; Lok, Shee-Mei.

Cell; 172(6): 1319-1334, 2018 03 08.

Artículo en Inglés | MEDLINE | ID: mdl-29522750

15.

A Bright Future for Antibiotics?

Matzov, Donna; Bashan, Anat; Yonath, Ada.

Annu Rev Biochem; 86: 567-583, 2017 06 20.

Artículo en Inglés | MEDLINE | ID: mdl-28654325

16.

The role of antibodies in HIV vaccines.

Mascola, John R; Montefiori, David C.

Annu Rev Immunol; 28: 413-44, 2010.

Artículo en Inglés | MEDLINE | ID: mdl-20192810

17.

Structure of the Adenosine A₁ Receptor Reveals the Basis for Subtype Selectivity.

Glukhova, Alisa; Thal, David M; Nguyen, Anh T; Vecchio, Elizabeth A; Jörg, Manuela; Scammells, Peter J; May, Lauren T; Sexton, Patrick M; Christopoulos, Arthur.

Cell; 168(5): 867-877.e13, 2017 02 23.

Artículo en Inglés | MEDLINE | ID: mdl-28235198

18.

Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.

Aggarwal, Anup; Parai, Maloy K; Shetty, Nishant; Wallis, Deeann; Woolhiser, Lisa; Hastings, Courtney; Dutta, Noton K; Galaviz, Stacy; Dhakal, Ramesh C; Shrestha, Rupesh; Wakabayashi, Shoko; Walpole, Chris; Matthews, David; Floyd, David; Scullion, Paul; Riley, Jennifer; Epemolu, Ola; Norval, Suzanne; Snavely, Thomas; Robertson, Gregory T; Rubin, Eric J; Ioerger, Thomas R; Sirgel, Frik A; van der Merwe, Ruben; van Helden, Paul D; Keller, Peter; Böttger, Erik C; Karakousis, Petros C; Lenaerts, Anne J; Sacchettini, James C.

Cell; 170(2): 249-259.e25, 2017 Jul 13.

Artículo en Inglés | MEDLINE | ID: mdl-28669536

19.

The p53 Pathway: Origins, Inactivation in Cancer, and Emerging Therapeutic Approaches.

Joerger, Andreas C; Fersht, Alan R.

Annu Rev Biochem; 85: 375-404, 2016 Jun 02.

Artículo en Inglés | MEDLINE | ID: mdl-27145840

20.

Partnering with Big Pharma-What Academics Need to Know.

Lipton, Stuart A; Nordstedt, Christer.

Cell; 165(3): 512-5, 2016 Apr 21.

Artículo en Inglés | MEDLINE | ID: mdl-27104971

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